This essay gives a broad overview of a team-taught course on Alexander Hamilton that merges discourses in music theory and political science. Authors describe pedagogical approaches to teaching both the musical "Hamilton" to non-musician students and Hamilton's history and politics to students not majoring in these fields. Contrasting challenges and outcomes of the seminar's first (2017) offering with its second (2020), authors consider the scope and implications of cultural intelligence and scholarly interdisciplinarity, maintaining that courses team-taught by instructors of different disciplines make connections across disciplines more explicit for students and enhance the transdisciplinary nature of the honors experience. Pre-course assessments are included, and future directions for team-teaching are discussed.