Distance learning is commonplace in higher education, with increasing numbers of students enjoying the flexibility e-learning provides. Keeping students connected with peers and instructors has been a challenge with e-learning, but as technology has advanced, the methods by which educators keep students engaged, synchronously and asynchronously, also have improved. This literature review presents support for both types of interaction; however, findings indicate educators must consider time constraints, technological ability, and motivation for students to interact in the online setting. Recommendations for implementing both synchronous and asynchronous interactions are made, including technological considerations. Finally, suggestions for research in distance learning are presented for consideration.