The purpose of this research was to construct a model of solid waste management based on multilateral cooperation in semi-urban community. Its specific objectives were to 1) study the solid waste situation and involvement of community in the solid waste management in Wangtaku Sub-district, Muang District, Nakhon Pathom Province; 2) construct a model of solid waste management based on multilateral cooperation in the semi-urban community of Wangtaku Sub-district; and 3) evaluate the efficiency of the model. The study followed the mixed method research design. The data were collected by using a questionnaire with 380 persons, in-depth interviews with 12 persons, and a focus group and an evaluation for the efficiency with 36 persons. The research results were as follows. 1) The situation and problems of solid waste in the community were at the high level (X-bar = 3.69) and the involvements of community in solid waste management were at the middle level (X-bar = 2.52). 2) The model of waste management based on multilateral cooperation in semi-urban community comprised occupational multilateral cooperation, solid waste management, local administrative organizations, community health promotion, and environmental networks. 3) Regarding the evaluation for efficiency of the model by the experts, the fitness of the model was at the highest level. The knowledge, awareness and practice about solid waste management of the participants with different genders, education levels, and occupations after joining the activity were increasingly higher than those of before joining the activity with statistical significance at the level of 0.05. The knowledge, awareness and practice about solid waste management of the participants with different genders, education levels, and occupations after joining the activity were not different.