The 2021 Youth Transition Report underscores the persistent and pernicious gap between youth and young adults with disabilities and those without disabilities on measures of success in education, employment, opportunity, and poverty. While data and reports exist for the working-age adult population and children with disabilities, the Institute for Educational Leadership (IEL) recognized a lack of information specific to the youth and young adult population in the 14-24 age group. IEL's Youth Transition Report addresses this need by presenting an annual snapshot of the outcome gaps between youth and young adults with disabilities and those without disabilities, including those opportunity youth whom the education and workforce systems have not adequately served and supported. This report consists of the status of the selected population, education, employment, opportunity youth, and poverty indicators. This report includes the analysis of key educational and employment indicators for youth and young adults with and without disabilities at both national and state levels. [For the 2020 report, see ED615626.]