COVID-19 was declared a pandemic by the World Health Organization and a public health emergency by the U.S. Centers for Disease Control in March 2020 (Centers for Disease Control and Prevention 2020). In the following months, families in the U.S. experienced financial hardships such as job and income loss, increasing food insecurity, and loss of child care (Gassman-Pines et al. 2020; Patrick et al. 2020). Historically, pandemics and diseases have had higher prevalence and impact in American Indian and Alaska Native (AIAN) communities (Kakol et al. 2020). Children and families in AIAN communities have also been disproportionately affected by the COVID-19 pandemic as well. Region XI Head Start programs are operated by federally recognized AIAN tribes and deliver comprehensive children's development services to economically disadvantaged children and families. Even while physically closed, Head Start programs and centers may have offered children and families valuable support during the COVID-19 pandemic. This brief focuses on how Region XI Head Start children's centers responded early in the COVID-19 pandemic to support children and families in Region XI. In the brief, the authors use information reported by center directors in June and July 2020 to describe how children's centers adjusted their communications and services with families during the early months of the COVID-19 pandemic. They first describe the strategies that children's centers used to communicate with families. They then examine the needs that families reported to center staff during the COVID-19 pandemic, and explore whether children's centers provided supports that correspond with those needs, on average. The brief concludes with a discussion how the services and referrals that children's centers provided to children and families changed during the early months of the COVID-19 pandemic. [The brief is cowritten with the AIAN FACES 2019 Workgroup.]