This handbook was created to provide National Education Association (NEA) member educators with a research-based description of the impact of poverty on teaching and learning. It is important to understand poverty's impact on children's educational success, along with strategies for overcoming the impact of poverty on the brain and learning. The handbook is divided into six sections. The first section identifies the symptoms of poverty manifested on school campuses and in the classroom. The second section addresses the risk factors and impact of poverty to the student, the family, the school, and the community. The third section identifies the science behind what is known about the impact of poverty and trauma on learning through researched-based studies. The fourth section addresses the role of educators in minimizing the effects of poverty and trauma on learning in their classrooms. The fifth section itemizes the long-term learnings that educators realize when teaching students from poverty. The sixth section provides actionable strategies that a school and educators can implement to make a difference in teaching students from poverty. Finally, the handbook provides a list of resources for educators to use in expanding their capacity to teach students from poverty.