University life is widely publicized as an adventure--a chance to engage with new ideas, people, and opportunities. While these vibrant interactions can be part of the college experience, participation in a competitive, high-stakes academic environment like University of Michigan (U-M) can pose very real challenges. Students must learn to navigate campus norms and culture, meet rigorous academic expectations, and manage financial, social, and personal pressures. Navigating these often-competing demands can create or exacerbate mental health concerns and jeopardize student well-being. In addition to these general complexities, individuals who hold identities that are marginalized in U.S. higher education spaces (e.g., students of color, LGBTQ+ students, undocumented students, students from low income families, international students) face additional burdens: emotional stress and labor arising from daily microaggressions, taunting, harassment, or worse. Mental health challenges are a common concern for students at U-M. Findings from the National Alliance on Mental Health's report "College Students Speak" (Gruttadaro & Crudo, 2012) show that 64% of students who have dropped out of college connect their departure to a mental health concern. In recent years, U-M's Counseling and Psychological Services unit (CAPS) has seen a surge in demand for its services. Their 2016-17 annual report highlights that service requests have nearly quadrupled since 2010, with an average increase of 5% per year that significantly exceeds U-M's annual increase in enrollment. In 2017-18, this annual increase continued with CAPS reporting a 6.7% increase from the previous academic year. The growth in demand for services, though alarming enough in its own right, is likely to be an underestimate of the actual incidence of mental health distress experienced by U-M students. Students may not access counseling support due to stigma surrounding mental health issues. They might also choose not to seek support via formal mechanisms because of cultural norms related to their identities or because of an actual or perceived lack of support professionals who share relevant identities. Both U-M students and instructors have identified a need for instructors to respond knowledgeably and compassionately to student mental health concerns. This Occasional Paper is designed to assist instructors in developing their capacity to support and assist students experiencing mental health concerns. It will introduce them to role-appropriate strategies to facilitate positive academic and health outcomes for their students, and shares strategies for proactively supporting student well-being. The paper presents principles that can proactively shape interactions with students who disclose a mild to moderate level of distress and distills best practices for responding to students experiencing severe distress.