This study examined how cultural values and teacher beliefs influence Chinese and Spanish university teachers' acceptance of ICTs by combining Hofstede's cultural values theory with technology acceptance theories. Four hundred and twenty-five university teachers from China and 385 teachers from Spain participated in the study. The proposed research model was tested by using samples from both countries and the multigroup analyses were performed to test moderating effects of cultural variables. Results confirmed the validity of the model in both samples and the effects of cultural values on the adoption of ICTs, and significant differences were observed between the two samples.