The world is increasingly merged into a global market economy, and the government's intervention power in economy has rapidly given way to that of science and technology. For the world's major economic powers, indigenous technological innovation has become a national strategy for enhancing competitiveness. Investment in scientific and technological innovation has become the most important form of strategic investment and strategic technological industry has become a forward-looking deployment and key priority in innovative national building. Research universities may have critical strength in and important social contribution to indigenous technological innovation. An innovative government may achieve this by making use of the research university's mechanism and characteristics of technology transfer, clarifying the university-industry relationship and providing relevant policy incentives. The article concludes with an analysis of the advantages, problems and making strategies of Chinese research universities in indigenous technological innovation.