This study examined academic staff utilization of Information and Communication Technology (ICT) in knowledge creation in universities in Cross River State. The study was guided by two research questions and one hypothesis. A questionnaire was developed, validated and used for data collection from a sample of 300 academic staff. Descriptive statistics (percentages) and inferential statistics (population t-test) were used to analyze the data collected for the study. Results revealed that provision of ICT tools by university management was inadequate, majority of the academic staff rated their ICT competence as low and the extent of academic staff utilization of ICT in knowledge creation activities was significantly low. Recommendations made include provision of ICT facilities for staff usage by university authorities and mandatory ICT training for all academic staff.