Introduction: The current study demonstrates empirical and cultural validity of "La Clave Profesional" (Spanish adaptation of Career Key, Jones's test based Holland's RIASEC model). The process of providing validity evidence also includes a reflection on personal and career development and examines the relationahsips between RIASEC types, personality traits and Spranger's Types of Men. Method: The participants in this study were 517 secondary students between the ages of 15 and 18, attending by Career Key, Holland's Self-Directed Serach, Spranger Lifestyle Test and the Cattell 16 PF. Results: The discrimination index of the items and internal consistency of scales have effectively shown the "La Clave Professional" is a very reliable instrument. Additional, validity procedures its relevant validity (criterion and construct). Futhermore, significant relationships were found between interest and personality factors. Discussion and conclusions: Results reveal the "La Clave Professional" has sufficient scientific and technical credibility for application to the Spanish population. Once Again, relationships between RIASEC scales, personality traits and lifestyle choices suggest the need for more research on enterprising, neurotic and extraverted types.