Given that many jobs of the future will be STEM jobs, that our K-12 system is "middle of the pack" in international comparisons, and that progress on STEM education at multiple levels is critical to building a just and inclusive society, there is an urgent need to continue to improve STEM education in the United States. Much knowledge for how to make progress exists. Federal agencies have the collective capacity to make a difference. This Strategic Plan identifies goals, priorities, and a new framework and mechanism for collaboration and program improvement. This Strategic Plan charts a course for sustained improvement and can help Federal investments in STEM education programs make a difference for many more students, educators, and members of the public. Implementation will require making hard choices, forging new partnerships, and focusing on outcomes. Adjustments along the way will be necessary, but the Federal agencies will work together to make progress on this national priority. Appended are: (1) The Federal Science, Technology, Engineering, and Mathematics (STEM) Education Portfolio: FY 2011; and (2) Instrument Design Principles.