Exercise usually refers to the physical activity in which one engages in order to achieve a healthier level of physical fitness. The integration of daily opportunities for physical activity for learners with Autism Spectrum Disorder (ASD) is important for improving their basic physical fitness. In addition to physical fitness, exercise also can be used as an intervention for learners with ASD to increase desired behaviors, such as academic engagement, time on task, correct responding, and task completion. Exercise can decrease inappropriate behaviors, such as aggression, self-injury, self-stimulatory/stereotypic behaviors, and time off task. This evidence-based practice (EBP) overview on Exercise (ECE) includes the following packet components: (1) Overview; (2) Evidence-base; (3) Step-by-Step Guide; (4) Implementation Checklist; (5) Data Collection Sheets; (6) Tip Sheet for Professionals; (7) Parent Guide; (8) Additional Resources; (9) CEC Standards; and (10) Module References. [This brief was co-written by the Autism Focused Intervention Resources and Modules (AFIRM) team.]