This report examines the relationship between students' participation in high-impact practices (HIP) and their perceived learning gains, with special attention paid to the nature of these relationships among Black and Hispanic students and among students 25 years or older. In 2018, with support from Lumina Foundation, the National Association of System Heads (NASH) launched an effort with four public college and university systems to demonstrate how a coordinated approach could expand and improve quality implementation of high-impact practices in an equitable manner. Drawing on National Survey of Student Engagement (NSSE) data involving more than 28,000 students from 15 institutions across three states participating in the Lumina-NASH initiative, this report assesses the benefits associated with participation in various HIPs in terms of students' academic and practical learning. Overall, analyses point to a substantial boost in perceived learning gains for students participating in HIPs, with an especially large benefit associated with participating in service-learning courses involving a community-based project. Participation in HIPs is strongly associated with learning gains for Black and Hispanic students as well as for students 25 years and older. However, analyses suggest that these relationships vary among the different HIPs measured by NSSE.