The present study aims to examine the relationship of career decision-making difficulties, dysfunctional career thoughts and generalized self-efficacy, as factors involved in the decision-making process for university students. The study also investigates the influence of demographics and individual variables, and examines the predictive power of the Career Decision-making Difficulties Questionnaire (CDDQ) and the Generalized Self-Efficacy Scale (GSE) over the dimensions assessed by the Career Thoughts Inventory (CTI). The results revealed statistically significant positive correlations between CDDQ factors (lack of information, inconsistent information, and lack of readiness) and total grade in Career Thoughts Inventory (CTI), decision-making confusion, commitment difficulty and lack of determination. On the other hand, the results show statistically significant negative correlations between all the aforementioned variables and generalized self-efficacy. Moreover, the generalized self-efficacy, as well as the CDDQ factors seemed to be predictors of the lack of determination, decision-making confusion and commitment difficulty. Finally, there is a discussion about the additionality of the CDDQ and CTI Questionnaires and advantages from their common use. Findings are discussed in the terms of the career counseling framework.