With the study reported on here I aimed to examine the mediating role of communication skills in the relationship between leadership styles and 21st-century skills. A correlational research design was employed to examine such relationships among the study variables. The study sample consisted of 542 pre-school, elementary school, middle school, and high school teachers. The participants were selected using a stratified sampling method. Three different instruments were used for data collection. To determine the normal distribution of the variables, normality tests were used after the data collection. For data analysis, Pearson's correlation was used to determine the relationship among the variables. The effect of study variables on one another were determined using multiple regression analysis. Lastly, the structural equation model was used to examine the mediating effect of communication skills in the relationship between leadership styles and 21st-century skills. The findings of the study show that there were significant relationships among the variables. The findings also indicate that communication skills had an indirect mediating effect on the relationship between leadership style and 21st-century skills.