Studies show that children may not be able to conceptualize some of the topics associated with anatomy, including internal organs and involuntary muscles, because the concepts are too abstract and are not easily visualized. Thus, this article presents activities that incorporate a variety of models and hands-on activities designed to provide preschool-age children with tactile experiences and investigations focusing on the human body. The activities build on each other in a learning progression, with more complex and abstract systems (i.e., the cardiovascular system) coming after students develop understandings of less abstract systems (i.e., musculoskeletal system). The lessons address three main ideas about the human body, focusing on how parts of our body help us by: (1) collecting information about the world around us (i.e., eyes, ears, nose, mouth, and skin); (2) moving, playing, and growing (i.e., muscles and bones); and (3) breathing and eating (i.e., heart, lungs, stomach, and intestines).