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Practicalities of Using a Modified Version of the Cochrane Collaboration Risk of Bias Tool for Randomised and Non-Randomised Study Designs Applied in a Health Technology Assessment Setting
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Robertson, Clare; Ramsay, Craig; Gurung, Tara; Mowatt, Graham; Pickard, Robert; Sharma, Pawana – Research Synthesis Methods, 2014
We describe our experience of using a modified version of the Cochrane risk of bias (RoB) tool for randomised and non-randomised comparative studies. Objectives: (1) To assess time to complete RoB assessment; (2) To assess inter-rater agreement; and (3) To explore the association between RoB and treatment effect size. Methods: Cochrane risk of…
Descriptors: Risk, Randomized Controlled Trials, Research Design, Comparative Analysis
Issues Relating to Study Design and Risk of Bias When Including Non-Randomized Studies in Systematic Reviews on the Effects of Interventions
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Higgins, Julian P. T.; Ramsay, Craig; Reeves, Barnaby C.; Deeks, Jonathan J.; Shea, Beverley; Valentine, Jeffrey C.; Tugwell, Peter; Wells, George – Research Synthesis Methods, 2013
Non-randomized studies may provide valuable evidence on the effects of interventions. They are the main source of evidence on the intended effects of some types of interventions and often provide the only evidence about the effects of interventions on long-term outcomes, rare events or adverse effects. Therefore, systematic reviews on the effects…
Descriptors: Research Methodology, Intervention, Program Effectiveness, Program Evaluation
An Introduction to Methodological Issues When Including Non-Randomised Studies in Systematic Reviews on the Effects of Interventions
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Reeves, Barnaby C.; Higgins, Julian P. T.; Ramsay, Craig; Shea, Beverley; Tugwell, Peter; Wells, George A. – Research Synthesis Methods, 2013
Background: Methods need to be further developed to include non-randomised studies (NRS) in systematic reviews of the effects of health care interventions. NRS are often required to answer questions about harms and interventions for which evidence from randomised controlled trials (RCTs) is not available. Methods used to review randomised…
Descriptors: Research Methodology, Research Design, Health Services, Workshops