This study explored the effect of video games as a new tool for Iranian EFL (English as a foreign language) vocabulary learning. To conduct the study, 40 intermediate EFL learners, both male and female, were chosen through a TOEFL proficiency test. The participants were divided into two groups (10 males and 10 females in each): a control group and an experimental group. While the control group studied vocabulary via traditional classes, the experimental group experienced vocabulary learning (the same words) via a video game called "Runaway: A Road Adventure." The results of the study revealed that learning vocabulary via video games is beneficial, and that males are more inclined toward video-game learning than females. (Contains 5 tables.)