The Dyslexia Pilot Project provided funding to school districts to implement a multitiered system of support (MTSS) framework for the prevention, early identification, and early intervention of reading difficulties. This article describes the evaluation of the multiyear Dyslexia Pilot Project for students in kindergarten through Grade 2. The evaluation extended a conceptual model for evaluating the systems effects of an MTSS for reading by including a cost-effectiveness analysis. The results indicate that mean rates of improvement on Dynamic Indicators for Basic Early Literacy Skills Next curriculum-based measures for students in participating schools exceeded the expected rates of improvement based on benchmark norms. This reduction in risk precluded the need for more intensive, individualized, and costly interventions and specialized educational services. Implications of the findings and future directions are discussed.