This multiple case study examines practices of educators in high schools called "odds-beaters". These schools are exemplary in that they consistently achieve better-than-predicted graduation outcomes among economically disadvantaged, African-American/Black, Hispanic/Latino, and English language learners. Findings from this study revealed that these schools are characterized in part by educators' priorities for an interdisciplinary specialization known as positive youth development (PYD). These priorities are expressed in how educators talk about young people; their use of PYD practices as a school improvement resource; and their strategies for facilitating students' engagement, agency, and identity development. The PYD practices evidenced in these schools offer insights for others and serve as a source for those struggling to improve college and career readiness among their diverse students.