This paper reports on a case study that examined the challenges faced and strategies adopted by Thai teachers when remote teaching during the COVID-19 pandemic. It further provides a comprehensive strategy for addressing the ongoing global pandemic in terms of education. We used a mixed methods design to collect both quantitative and qualitative data from K-12 Thai teachers (N = 235) and performed 42 semi-structured interviews. The results indicated that most Thai teachers have the necessary knowledge to design suitable content for remote teaching. However, they must further develop their administration and leadership skills. The main challenges and strategies for Thai teachers remain in the areas of student motivation, assessment, and classroom management. Furthermore, ranking from high to low, Thai teachers preferred face-to-face instruction, blended/hybrid instruction and hyflex among different instructional delivery modalities. We conclude the paper by discussing possible alternative instructional delivery modalities and their implications for K-12 remote learning and instruction.