School and life achievement patterns for girls and women differ from those of boys and men. While girls have made dramatic progress in school, they need to be inspired to connect to lifelong achievement. Both research and clinical work at the Ohio-based Family Achievement Clinic find that more boys than girls underachieve in school. There is much that parents and teachers can do to help both genders achieve their full potential. This article discusses different challenges that boys and girls face in academic settings, and provides possible solutions to each challenge.