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ChABC Infusions into Medial Prefrontal Cortex, but Not Posterior Parietal Cortex, Improve the Performance of Rats Tested on a Novel, Challenging Delay in the Touchscreen TUNL Task
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Anderson, Michael D.; Paylor, John W.; Scott, Gavin A.; Greba, Quentin; Winship, Ian R.; Howland, John G. – Learning & Memory, 2020
Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround subsets of neurons throughout the central nervous system (CNS). They are made up of chondroitin sulfate proteoglycans (CSPGs), hyaluronan, tenascin-R, and many other link proteins that together make up their rigid and lattice-like structure. Modulation of PNNs…
Descriptors: Animals, Brain Hemisphere Functions, Novelty (Stimulus Dimension), Neurological Impairments
Roles of the Medial Prefrontal Cortex, Mediodorsal Thalamus, and Their Combined Circuit for Performance of the Odor Span Task in Rats: Analysis of Memory Capacity and Foraging Behavior
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Scott, Gavin A.; Liu, Max C.; Tahir, Nimra B.; Zabder, Nadine K.; Song, Yuanyi; Greba, Quentin; Howland, John G. – Learning & Memory, 2020
Working memory (WM), the capacity for short-term storage of small quantities of information for immediate use, is thought to depend on activity within the prefrontal cortex. Recent evidence indicates that the prefrontal neuronal activity supporting WM is driven by thalamocortical connections arising in mediodorsal thalamus (mdThal). However, the…
Descriptors: Role, Animals, Brain Hemisphere Functions, Short Term Memory
Medial Prefrontal Cortex and Dorsomedial Striatum Are Necessary for the Trial-Unique, Delayed Nonmatching-to-Location (TUNL) Task in Rats: Role of NMDA Receptors
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Davies, Don A.; Hurtubise, Jessica L.; Greba, Quentin; Howland, John G. – Learning & Memory, 2017
The trial-unique, delayed nonmatching-to-location (TUNL) task is a recently developed behavioral task that measures spatial working memory and a form of pattern separation in touchscreen-equipped operant conditioning chambers. Limited information exists regarding the neurotransmitters and neural substrates involved in the task. The present…
Descriptors: Brain Hemisphere Functions, Brain, Short Term Memory, Neurological Organization
Interactions between Medial Prefrontal Cortex and Dorsomedial Striatum Are Necessary for Odor Span Capacity in Rats: Role of GluN2B-Containing NMDA Receptors
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Davies, Don A.; Greba, Quentin; Selk, Jantz C.; Catton, Jillian K.; Baillie, Landon D.; Mulligan, Sean J.; Howland, John G. – Learning & Memory, 2017
Working memory is involved in the maintenance and manipulation of information essential for complex cognition. While the neural substrates underlying working memory capacity have been studied in humans, considerably less is known about the circuitry mediating working memory capacity in rodents. Therefore, the present experiments tested the…
Descriptors: Short Term Memory, Animals, Cognitive Processes, Neurological Organization
Inactivation of Medial Prefrontal Cortex or Acute Stress Impairs Odor Span in Rats
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Davies, Don A.; Molder, Joel J.; Greba, Quentin; Howland, John G. – Learning & Memory, 2013
The capacity of working memory is limited and is altered in brain disorders including schizophrenia. In rodent working memory tasks, capacity is typically not measured (at least not explicitly). One task that does measure working memory capacity is the odor span task (OST) developed by Dudchenko and colleagues. In separate experiments, the effects…
Descriptors: Brain Hemisphere Functions, Stress Variables, Olfactory Perception, Animals
Odor Preference Learning and Memory Modify GluA1 Phosphorylation and GluA1 Distribution in the Neonate Rat Olfactory Bulb: Testing the AMPA Receptor Hypothesis in an Appetitive Learning Model
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Cui, Wen; Darby-King, Andrea; Grimes, Matthew T.; Howland, John G.; Wang, Yu Tian; McLean, John H.; Harley, Carolyn W. – Learning & Memory, 2011
An increase in synaptic AMPA receptors is hypothesized to mediate learning and memory. AMPA receptor increases have been reported in aversive learning models, although it is not clear if they are seen with memory maintenance. Here we examine AMPA receptor changes in a cAMP/PKA/CREB-dependent appetitive learning model: odor preference learning in…
Descriptors: Animals, Neonates, Memory, Learning Processes
AMPA Receptor Endocytosis in Rat Perirhinal Cortex Underlies Retrieval of Object Memory
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Cazakoff, Brittany N.; Howland, John G. – Learning & Memory, 2011
Mechanisms consistent with long-term depression in the perirhinal cortex (PRh) play a fundamental role in object recognition memory; however, whether AMPA receptor endocytosis is involved in distinct phases of recognition memory is not known. To address this question, we used local PRh infusions of the cell membrane-permeable Tat-GluA2[subscript…
Descriptors: Recognition (Psychology), Depression (Psychology), Brain Hemisphere Functions, Role