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Direct linkNartey, Michaelina N.; Peña-Castillo, Lourdes; LeGrow, Megan; Doré, Jules; Bhattacharya, Sriya; Darby-King, Andrea; Carew, Samantha J.; Yuan, Qi; Harley, Carolyn W.; McLean, John H. – Learning & Memory, 2020
In the olfactory bulb, a cAMP/PKA/CREB-dependent form of learning occurs in the first week of life that provides a unique mammalian model for defining the epigenetic role of this evolutionarily ancient plasticity cascade. Odor preference learning in the week-old rat pup is rapidly induced by a 10-min pairing of odor and stroking. Memory is…
Descriptors: Animals, Genetics, Learning, Olfactory Perception
Grimes, Matthew T.; Powell, Maria; Gutierrez, Sandra Mohammed; Darby-King, Andrea; Harley, Carolyn W.; McLean, John H. – Learning & Memory, 2015
Here we examine the role of the exchange protein directly activated by cAMP (Epac) in ß-adrenergic-dependent associative odor preference learning in rat pups. Bulbar Epac agonist (8-pCPT-2-O-Me-cAMP, or 8-pCPT) infusions, paired with odor, initiated preference learning, which was selective for the paired odor. Interestingly, pairing odor with Epac…
Descriptors: Animals, Olfactory Perception, Biochemistry, Role
Grimes, Matthew T.; Harley, Carolyn W.; Darby-King, Andrea; McLean, John H. – Learning & Memory, 2012
Neonatal odor-preference memory in rat pups is a well-defined associative mammalian memory model dependent on cAMP. Previous work from this laboratory demonstrates three phases of neonatal odor-preference memory: short-term (translation-independent), intermediate-term (translation-dependent), and long-term (transcription- and…
Descriptors: Animals, Olfactory Perception, Preferences, Learning
Cui, Wen; Darby-King, Andrea; Grimes, Matthew T.; Howland, John G.; Wang, Yu Tian; McLean, John H.; Harley, Carolyn W. – Learning & Memory, 2011
An increase in synaptic AMPA receptors is hypothesized to mediate learning and memory. AMPA receptor increases have been reported in aversive learning models, although it is not clear if they are seen with memory maintenance. Here we examine AMPA receptor changes in a cAMP/PKA/CREB-dependent appetitive learning model: odor preference learning in…
Descriptors: Animals, Neonates, Memory, Learning Processes
Cui, Wen; Smith, Andrew; Darby-King, Andrea; Harley, Carolyn W.; McLean, John H. – Learning & Memory, 2007
Increases in cyclic adenosine monophosphate (cAMP) are proposed to initiate learning in a wide variety of species. Here, we measure changes in cAMP in the olfactory bulb prior to, during, and following a classically conditioned odor preference trial in rat pups. Measurements were taken up to the point of maximal CREB phosphorylation in olfactory…
Descriptors: Classical Conditioning, Nonverbal Learning, Animals, Discrimination Learning
Harley, Carolyn W.; Darby-King, Andrea; McCann, Jennifer; McLean, John H. – Learning & Memory, 2006
We proposed that mitral cell [beta]1-adrenoceptor activation mediates rat pup odor preference learning. Here we evaluate [beta]1-, [beta]2-, [alpha]1-, and [alpha]2-adrenoceptor agonists in such learning. The [beta]1-adrenoceptor agonist, dobutamine, and the [alpha]1-adrenoceptor agonist, phenylephrine, induced learning, and both exhibited an…
Descriptors: Molecular Structure, Learning Processes, Animals, Brain
