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Stevanovic, Korey D.; Fry, Sydney A.; DeFilipp, Jemma M. S.; Wu, Nicholas; Bernstein, Briana J.; Cushman, Jesse D. – Learning & Memory, 2022
Inclusion of male and female subjects in behavioral neuroscience research requires a concerted effort to characterize sex differences in standardized behavioral assays. Sex differences in hippocampus-dependent assays have been widely reported but are still poorly characterized. In the present study, we conducted a parametric analysis of…
Descriptors: Sex, Gender Differences, Brain Hemisphere Functions, Genetics
Fry, Benjamin R.; Pence, Nathan T.; McLocklin, Andrew; Johnson, Alexander W. – Learning & Memory, 2021
The dopamine system has been implicated in decision-making particularly when associated with effortful behavior. We examined acute optogenetic stimulation of dopamine cells in the ventral tegmental area (VTA) as mice engaged in an effort-based decision-making task. Tyrosine hydroxylase-Cre mice were injected with Cre-dependent ChR2 or eYFP control…
Descriptors: Decision Making, Brain, Cognitive Processes, Stimulation
Martin, Kiley; Musaus, Madeline; Navabpour, Shaghayegh; Gustin, Aspen; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J. – Learning & Memory, 2021
Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin protein targeting in the dorsal hippocampus, the…
Descriptors: Fear, Memory, Gender Differences, Animals
Schultz, Maria N.; Crawley, Jacqueline N. – Learning & Memory, 2020
Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the maternal allele of the gene "Ube3a." The primary symptoms of Angelman syndrome are severe cognitive deficits, impaired motor functions, and speech disabilities. Analogous phenotypes have been detected in young adult "Ube3a" mice. Here, we…
Descriptors: Neurological Impairments, Genetics, Genetic Disorders, Symptoms (Individual Disorders)
Heuer, Sarah E.; Neuner, Sarah M.; Hadad, Niran; O'Connell, Kristen M. S.; Williams, Robert W.; Philip, Vivek M.; Gaiteri, Chris; Kaczorowski, Catherine C. – Learning & Memory, 2020
Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and behavioral data from a mouse population designed to model human variation in cognitive outcomes to…
Descriptors: Cognitive Processes, Resilience (Psychology), Alzheimers Disease, Genetics
Rogers, Jack T.; Cahill, Catherine M. – Learning & Memory, 2020
A set of common-acting iron-responsive 5'untranslated region (5'UTR) motifs can fold into RNA stem loops that appear significant to the biology of cognitive declines of Parkinson's disease dementia (PDD), Lewy body dementia (LDD), and Alzheimer's disease (AD). Neurodegenerative diseases exhibit perturbations of iron homeostasis in defined brain…
Descriptors: Neurological Impairments, Dementia, Brain, Cognitive Processes
ApoE Isoform-Specific Differences in Behavior and Cognition Associated with Subchronic MPTP Exposure
Torres, Eileen Ruth S.; Boutros, Sydney Weber; Meshul, Charles K.; Raber, Jacob – Learning & Memory, 2020
Parkinson's disease (PD) is characterized clinically by progressive motor dysfunction; overt parkinsonism is often preceded by prodromal symptoms including disturbances in the sleep-wake cycle. Up to 80% of patients with PD also develop dementia. In humans, there are three major apolipoprotein E isoforms: E2, E3, and E4. Increased rate of dementia…
Descriptors: Neurological Impairments, Dementia, Genetics, Animals
Nartey, Michaelina N.; Peña-Castillo, Lourdes; LeGrow, Megan; Doré, Jules; Bhattacharya, Sriya; Darby-King, Andrea; Carew, Samantha J.; Yuan, Qi; Harley, Carolyn W.; McLean, John H. – Learning & Memory, 2020
In the olfactory bulb, a cAMP/PKA/CREB-dependent form of learning occurs in the first week of life that provides a unique mammalian model for defining the epigenetic role of this evolutionarily ancient plasticity cascade. Odor preference learning in the week-old rat pup is rapidly induced by a 10-min pairing of odor and stroking. Memory is…
Descriptors: Animals, Genetics, Learning, Olfactory Perception
Sathiyakumar, Sankirthana; Carrasco, Sofia Skromne; Saad, Lydia; Richards, Blake A. – Learning & Memory, 2020
Behavioral flexibility is important in a changing environment. Previous research suggests that systems consolidation, a long-term poststorage process that alters memory traces, may reduce behavioral flexibility. However, exactly how systems consolidation affects flexibility is unknown. Here, we tested how systems consolidation affects: (1)…
Descriptors: Memory, Animals, Rewards, Food
Vousden, George H.; Paulcan, Sloane; Robbins, Trevor W.; Eagle, Dawn M.; Milton, Amy L. – Learning & Memory, 2020
In obsessive-compulsive disorder (OCD), functional behaviors such as checking that a door is locked become dysfunctional, maladaptive, and debilitating. However, it is currently unknown how aversive and appetitive motivations interact to produce functional and dysfunctional behavior in OCD. Here we show a double dissociation in the effects of…
Descriptors: Animal Behavior, Cues, Task Analysis, Punishment
Sekeres, Melanie J.; Moscovitch, Morris; Grady, Cheryl L.; Sullens, D. Gregory; Winocur, Gordon – Learning & Memory, 2020
Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a…
Descriptors: Memory, Animals, Brain Hemisphere Functions, Conditioning
Oruro, Enver Miguel; Pardo, Grace V. E.; Lucion, Aldo B.; Calcagnotto, Maria Elisa; Idiart, Marco A. P. – Learning & Memory, 2020
Studies have shown that neonate rodents exhibit high ability to learn a preference for novel odors associated with thermo-tactile stimuli that mimics maternal care. Artificial odors paired with vigorous strokes in rat pups younger than 10 postnatal days (P), but not older, rapidly induce an orientation-approximation behavior toward the conditioned…
Descriptors: Animal Behavior, Cytology, Learning Processes, Preferences
Alexandrescu, Anamaria; Carew, Thomas J. – Learning & Memory, 2020
The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of "Aplysia" cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term…
Descriptors: Brain Hemisphere Functions, Memory, Spatial Ability, Sensory Integration