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Creighton, Samantha D.; Jardine, Kristen H.; Desimone, Alexa; Zmetana, Megan; Castellano, Sabrina; Milite, Ciro; Sbardella, Gianluca; Winters, Boyer D. – Learning & Memory, 2022
Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional…
Descriptors: Alzheimers Disease, Animals, Research, Spatial Ability
Gonzalez, Maria Carolina; Radiske, Andressa; Conde-Ocazionez, Sergio; Rossato, Janine I.; Bevilaqua, Lia R. M.; Cammarota, Martín – Learning & Memory, 2022
Hippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelty and memory processing. We found that, in adult male rats, ORM recall in the presence of a novel object, but…
Descriptors: Recall (Psychology), Brain Hemisphere Functions, Biochemistry, Neurological Impairments
Szollosi, Ágnes; Kéri, Szabolcs; Racsmány, Mihály – Learning & Memory, 2022
Some previous studies have shown that increased stress hormone levels have beneficial effects on memory encoding; however, there is no clear consensus on which encoding-related processes are affected by stress hormones. In the present study, we investigated the relationship between interindividual differences in neuroendocrine response to acute…
Descriptors: Memory, Cognitive Processes, Stress Variables, Recognition (Psychology)
Sahoo, Biswaranjan; Sharma, Shiv K. – Learning & Memory, 2022
A critical role of protein modifications such as phosphorylation and acetylation in synaptic plasticity and memory is well documented. Tyrosine sulfation plays important roles in several biological processes. However, its role in synaptic plasticity and memory is not well understood. Here, we show that sulfation contributes to long-term…
Descriptors: Long Term Memory, Biochemistry, Brain Hemisphere Functions, Spatial Ability
Sayegh, Fares; Herraiz, Laurie; Colom, Morgane; Lopez, Sébastien; Rampon, Claire; Dahan, Lionel – Learning & Memory, 2022
Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal…
Descriptors: Cognitive Processes, Memory, Fear, Conditioning
Hellerstedt, Robin; Talmi, Deborah – Learning & Memory, 2022
Reward is thought to attenuate forgetting through the automatic effect of dopamine on hippocampal memory traces. Here we report a conceptual replication of previous results where we did not observe this effect of reward. Participants encoded eight lists of pictures and recalled picture content immediately or the next day. They were informed that…
Descriptors: Rewards, Recall (Psychology), Brain Hemisphere Functions, Memory
Amorim, Felippe E.; Chapot, Renata L.; Chapot, Renata L.; Lee, Jonathan L. C.; Amaral, Olavo B. – Learning & Memory, 2021
Remembering is not a static process: When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine…
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Behavior Patterns
Fulton, Sasha L.; Hsieh, Changchi; Atkin, Tobias; Norris, Ryan; Schoenfeld, Eric; Tsokas, Panayiotis; Fenton, André Antonio; Sacktor, Todd Charlton; Coplan, Jeremy D. – Learning & Memory, 2021
Protein kinase M[zeta] (PKM[zeta]) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is a precursor to adult mood and anxiety disorders, in part, through persistent disruption of emotional memory throughout life. Here we subjected 10- to 16-wk-old male bonnet…
Descriptors: Brain Hemisphere Functions, Animals, Memory, Biochemistry
Martin, Kiley; Musaus, Madeline; Navabpour, Shaghayegh; Gustin, Aspen; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J. – Learning & Memory, 2021
Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin protein targeting in the dorsal hippocampus, the…
Descriptors: Fear, Memory, Gender Differences, Animals
Trask, Sydney; Reis, David S.; Ferrara, Nicole C.; Helmstetter, Fred J. – Learning & Memory, 2020
Relative to males, female rats can show enhanced contextual fear generalization (demonstrating a fear response in a safe or neutral context) dependent on estrogen receptor activation. The current experiment aimed to extend this finding to cued fear conditioning. Females in low-estrogen phases of the estrous cycle showed good discrimination,…
Descriptors: Animals, Gender Differences, Metabolism, Fear
Vazquez, Maribel; Frazier, Jessica H.; Reichel, Carmela M.; Peters, Jamie – Learning & Memory, 2020
Females are at higher risk for certain opioid addictive behaviors, but the influence of ovarian hormones is unknown. In our rat model of heroin self-administration, females exhibited higher relapse rates that correlated with rates of heroin seeking on the first extinction session. We administered estradiol alone, or in combination with…
Descriptors: Females, Narcotics, Addictive Behavior, Biochemistry
Alexandrescu, Anamaria; Carew, Thomas J. – Learning & Memory, 2020
The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of "Aplysia" cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term…
Descriptors: Brain Hemisphere Functions, Memory, Spatial Ability, Sensory Integration