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Direct linkAnderson, Michael D.; Paylor, John W.; Scott, Gavin A.; Greba, Quentin; Winship, Ian R.; Howland, John G. – Learning & Memory, 2020
Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround subsets of neurons throughout the central nervous system (CNS). They are made up of chondroitin sulfate proteoglycans (CSPGs), hyaluronan, tenascin-R, and many other link proteins that together make up their rigid and lattice-like structure. Modulation of PNNs…
Descriptors: Animals, Brain Hemisphere Functions, Novelty (Stimulus Dimension), Neurological Impairments
Scott, Gavin A.; Liu, Max C.; Tahir, Nimra B.; Zabder, Nadine K.; Song, Yuanyi; Greba, Quentin; Howland, John G. – Learning & Memory, 2020
Working memory (WM), the capacity for short-term storage of small quantities of information for immediate use, is thought to depend on activity within the prefrontal cortex. Recent evidence indicates that the prefrontal neuronal activity supporting WM is driven by thalamocortical connections arising in mediodorsal thalamus (mdThal). However, the…
Descriptors: Role, Animals, Brain Hemisphere Functions, Short Term Memory
