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Direct linkOstroff, Linnaea E.; Cain, Christopher K. – Learning & Memory, 2022
Local protein synthesis at synapses can provide a rapid supply of proteins to support synaptic changes during consolidation of new memories, but its role in the maintenance or updating of established memories is unknown. Consolidation requires new protein synthesis in the period immediately following learning, whereas established memories are…
Descriptors: Long Term Memory, Associative Learning, Brain, Cognitive Processes
Laughlin, Lindsay C.; Moloney, Danielle M.; Samels, Shanna B.; Sears, Robert M.; Cain, Christopher K. – Learning & Memory, 2020
In signaled active avoidance (SigAA), rats learn to suppress Pavlovian freezing and emit actions to remove threats and prevent footshocks. SigAA is critical for understanding aversively motivated instrumental behavior and anxiety-related active coping. However, with standard protocols ~25% of rats exhibit high freezing and poor avoidance. This has…
Descriptors: Animals, Behavior Modification, Coping, Fear
