The Wearable Device Challenge was developed at the Nanosystems Engineering Research Center for Advanced Self-Powered Systems of Integrated Sensors and Technologies (ASSIST). The Challenge is rooted in the research and innovation ecosystem of the Center and its vision: to have a transformational impact on the way doctors and patients manage wellness through wearable, self-powered health and environmental monitoring systems. At its core, the program teaches middle and high school teachers and students how to apply the engineering design process to solve real-world problems through a project-based approach. The program impacts several hundred students in North Carolina annually through real-world, relevant, hands-on engineering design challenges. Teachers are empowered to introduce engineering design into a variety of both formal and informal educational settings, and students are given the opportunity to explore exciting, cutting-edge applications of science and technology that will inspire them to continue in science, technology, engineering, and mathematics fields.