The study investigated the use of ICTs in student support in Open and Distance learning (ODL) at Makerere University. The study adopted a survey design with 327 ODL students, and the data from participants was collected using self-administered questionnaires and individual interviews. The results showed that Makerere University has enhanced student support through the introduction of the learning management systems, web-based applications, registration and accessing results to ensure students' satisfaction and retention in ODL system. However, limited electronic support is extended to ODL students through e-mails, mobile phones, social media applications, radio and television. The study concludes with recommendations to policy makers at Makerere University. Although this study was based in Uganda, the findings may be of relevance to institutions in other developing countries.