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Direct linkSacrey, Lori-Ann R.; Zwaigenbaum, Lonnie; Bryson, Susan; Brian, Jessica; Smith, Isabel M.; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Journal of Autism and Developmental Disorders, 2021
Despite considerable progress in characterizing the early signs of autism spectrum disorder (ASD), more remains to be learned about how symptoms emerge in the first year of life. Parents with a new baby who already had at least one biological child diagnosed with ASD (high-risk) or no family history of ASD (low-risk) completed two measures when…
Descriptors: Siblings, Screening Tests, Autism, Pervasive Developmental Disorders
Raza, Sarah; Sacrey, Lori-Ann R.; Zwaigenbaum, Lonnie; Bryson, Susan; Brian, Jessica; Smith, Isabel M.; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Journal of Autism and Developmental Disorders, 2020
Social-emotional behavior in autism spectrum disorder (ASD) was examined among high-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers. Caregivers completed the Infant-Toddler Social Emotional Assessment (ITSEA) at 18 months, and blind diagnostic assessment for ASD was conducted at 36 months.…
Descriptors: Autism, Pervasive Developmental Disorders, Genetics, Clinical Diagnosis
Lee, Helen Y.; Vigen, Cheryl; Zwaigenbaum, Lonnie; Bryson, Susan; Smith, Isabel; Brian, Jessica; Watson, Linda R.; Crais, Elizabeth R.; Turner-Brown, Lauren; Reznick, J. Steven; Baranek, Grace T. – Journal of Autism and Developmental Disorders, 2019
This study examined the performance of the First Year Inventory (FYI; version 2.0), a community-normed parent-reported screening instrument, in a high-risk (HR) sample of 12-month-olds with older siblings diagnosed with autism spectrum disorder (ASD). The FYI 2.0 was completed by parents of 86 HR infants and 35 low-risk control infants at age…
Descriptors: Toddlers, Screening Tests, At Risk Persons, Autism
Raza, Sarah; Zwaigenbaum, Lonnie; Sacrey, Lori-Ann R.; Bryson, Susan; Brian, Jessica; Smith, Isabel M.; Reid, Kyle; Roberts, Wendy; Szatmari, Peter; Vaillancourt, Tracy; Roncadin, Caroline; Garon, Nancy – Journal of Autism and Developmental Disorders, 2019
This study examined the potential of the short form of the Quantitative Checklist for Autism in Toddlers (Q-CHAT-10) to identify autism spectrum disorder (ASD) in a high-risk sibling cohort. High-risk (HR; siblings of children diagnosed with ASD) and low-risk (LR; no family history of ASD) toddlers were assessed prospectively at 18 and 24 months…
Descriptors: Autism, Pervasive Developmental Disorders, Toddlers, At Risk Persons
Estes, Annette; Munson, Jeffrey; St. John, Tanya; Dager, Stephen R.; Rodda, Amy; Botteron, Kelly; Hazlett, Heather; Schultz, Robert T.; Zwaigenbaum, Lonnie; Piven, Joseph; Guralnick, Michael J.; Chappell, J. C.; Dager, S.; Shaw, D; McKinstry, R.; Constantino, J.; Pruett, J.; Schultz, R.; Paterson, S.; Evans, A. C.; Collins, D. L.; Pike, G. B.; Kostopolous, P.; Das, S.; Gerig, G.; Styner, M.; Gu, H.; Sullivan, P.; Wright, G. – Journal of Autism and Developmental Disorders, 2018
Preschool-aged siblings of children with ASD are at high-risk (HR) for ASD and related challenges, but little is known about their emerging peer competence and friendships. Parents are the main providers of peer-relationship opportunities during preschool. Understanding parental challenges supporting early peer relationships is needed for optimal…
Descriptors: Parents, Parent Participation, Peer Relationship, Birth Order
Dimian, Adele F.; Botteron, Kelly N.; Dager, Stephen R.; Elison, Jed T.; Estes, Annette M.; Pruett, John R., Jr.; Schultz, Robert T.; Zwaigenbaum, Lonnie; Piven, Joseph; Wolff, Jason J. – Journal of Autism and Developmental Disorders, 2017
Prevalence of self-injurious behavior (SIB) is as high as 50% among children with autism spectrum disorder (ASD). Identification of risk factors for the development of SIB is critical to early intervention and prevention. However, there is little empirical research utilizing a prospective design to identify early risk factors for SIB. The purpose…
Descriptors: Risk, Self Destructive Behavior, Autism, Pervasive Developmental Disorders
Germani, Tamara; Zwaigenbaum, Lonnie; Bryson, Susan; Brian, Jessica; Smith, Isabel; Roberts, Wendy; Szatmari, Peter; Roncadin, Caroline; Sacrey, Lori Ann R.; Garon, Nancy; Vaillancourt, Tracy – Journal of Autism and Developmental Disorders, 2014
This study assessed sensory processing differences between 24-month infants at high-risk of autism spectrum disorder (ASD), each with an older sibling with ASD, and low-risk infants with no family history of ASD. Sensory processing differences were assessed using the Infant/Toddler Sensory Profile, a parent-reported measure. Groups were compared…
Descriptors: Pervasive Developmental Disorders, Autism, Siblings, Infants
Zwaigenbaum, Lonnie; Bryson, Susan E.; Szatmari, Peter; Brian, Jessica; Smith, Isabel M.; Roberts, Wendy; Vaillancourt, Tracy; Roncadin, Caroline – Journal of Autism and Developmental Disorders, 2012
Sex differences were examined in 3-year-olds with autism spectrum disorders (ASD) ascertained from a high-risk cohort, and high- and low-risk comparison groups. Participants included 319 high-risk siblings and 129 low-risk controls. Eighty-five siblings were diagnosed with ASD, including 57 of 176 boys (32.4%) and 28 of 143 girls (19.6%), implying…
Descriptors: Females, Autism, Males, Siblings
Banach, Ryan; Thompson, Ann; Szatmari, Peter; Goldberg, Jeremy; Tuff, Lawrence; Zwaigenbaum, Lonnie; Mahoney, William – Journal of Autism and Developmental Disorders, 2009
It has been proposed that females at risk for autism are protected in some way, so that only those with the greatest genetic liability are affected. Consequently, affected male siblings of females with autism should be more impaired than affected male siblings of male probands. One hundred and ninety-four (194) families with a single child with…
Descriptors: Siblings, Females, Autism, Intelligence Quotient
Bryson, Susan E.; Zwaigenbaum, Lonnie; Mcdermott, Catherine; Rombough, Vicki; Brian, Jessica – Journal of Autism and Developmental Disorders, 2008
The Autism Observation Scale for Infants (AOSI) was developed to detect and monitor early signs of autism as they emerge in high-risk infants (all with an older sibling with an autistic spectrum disorder). Here we describe the scale and its development, and provide preliminary data on its reliability. Inter-rater reliability both for total scores…
Descriptors: Observation, Autism, Interrater Reliability, Infants
Loh, Alvin; Soman, Teesta; Brian, Jessica; Bryson, Susan E.; Roberts, Wendy; Szatmari, Peter; Smith, Isabel M.; Zwaigenbaum, Lonnie – Journal of Autism and Developmental Disorders, 2007
This study examined motor behaviors in a longitudinal cohort of infant siblings of children with autism. Stereotypic movements and postures occurring during standardized observational assessments at 12 and 18 months were coded from videotapes. Participants included eight infant siblings later diagnosed with autism spectrum disorder (ASD), a random…
Descriptors: Infants, Siblings, Autism, Antisocial Behavior
Zwaigenbaum, Lonnie; Thurm, Audrey; Stone, Wendy; Baranek, Grace; Bryson, Susan; Iverson, Jana; Kau, Alice; Klin, Ami; Lord, Cathy; Landa, Rebecca; Rogers, Sally; Sigman, Marian – Journal of Autism and Developmental Disorders, 2007
Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective…
Descriptors: Infants, Siblings, Autism, At Risk Persons
Szatmari, Peter; Zwaigenbaum, Lonnie; Bryson, Susan – Journal of Autism and Developmental Disorders, 2004
The objective of this review is to clarify the role of matching in family genetic studies of autism as a way of defining endophenotypes for linkage analysis. The concept of a confounding variable is reviewed and the importance of considering these in family studies of three endophenotypes in autism are considered: cognitive/language impairments,…
Descriptors: Genetics, Epidemiology, Siblings, Family (Sociological Unit)
