As globalization increases and the international community moves toward greater interdependence, international learning experiences have become a core educational value for many American universities. Although there are various approaches to study abroad programming, the Semester at Sea (SAS) voyage is an understudied global education program. Using a sample of college students (N = 73), the present study examined differences between the cultural sensitivity and global mindedness scores of students prior to starting the SAS voyage and at the culmination of the voyage. The findings demonstrate significant increases in both global mindedness and cultural sensitivity at the completion of the program and support the positive role of cultural immersion experiences in student growth. Recommendations for future research and study abroad programming are also discussed.