Fostering adolescents' self-efficacy and positive emotions through learning contexts which induce beneficial achievement goals can prevent motivational decline in adolescents. Achievement goal theory states that the learning context and gender moderate the interplay of self-efficacy, emotions, and achievement goals. This study compared female and male students in teacher-directed learning (TL) with those of students in a learning context based on self-directed learning (SL). With data gathered from questionnaires completed by 828 adolescents (7th/8th grades; M[subscript Age] = 13.6; SD = 0.88), latent mean comparison revealed that female as well as male adolescents in SL report higher means in mastery goals and positive emotions. Results of multigroup structural equation modeling showed that for both female and male students in SL, solely mastery goals are significantly related to both positive emotions and self-efficacy, whereas boys and girls in TL showed different associations: In particular, boys in TL seem to have disadvantageous patterns based on work avoidance orientation.