Job burnout is a problem characterized by physical and mental problems caused by intense working conditions. In recent years, many teachers on a global scale have stated that they have experienced job burnout. It is known that many teachers who experience job burnout report sleep, fatigue, desire to quit work, low level of professional satisfaction and wellbeing. Although it is known that there are negative relationships between mindfulness, self-efficacy in classroom management, and job burnout, no research has been encountered to examine these concepts in the context of education. This study examined the mediating role of classroom management self-efficacy in the relationship between classroom mindfulness and teacher burnout. The research sample consists of 288 teachers, 185 women (64.2%) and 103 men (35.8%). In the preliminary analysis, for detecting multicollinearity Harmon's Single Factor Test and for normality Skewness and Kurtosis were tested. The goodness of fit values of the tested model was found as X[superscript 2] / df=1.17, CFI=0.99, TLI=0.99, GFI=0.99 and RMSEA=0.03. Since the path between mindfulness and job burnout in teaching is significant in the model, it is understood that self-efficacy in classroom management is a partial mediator in the relationship between mindfulness in teaching and job burnout. Mindfulness in the teaching profession is believed to play a key role in both self-efficacy in classroom management and burnout in the profession. For this reason, mindfulness in the classroom should be included in both in-service teacher training and professional development.