The purpose of the current study is to investigate middle school students' self-regulation skills and vocabulary learning strategies in foreign language. The sampling of the current study consists of 990 5th, 6th, 7th and 8th grade middle school students attending state middle schools in the Mentese district of the city of Mugla, Turkey in school year 2018-2019. As the data collection tools, the Perceived Self-Regulation Scale and the Vocabulary Learning Strategies in Foreign Language Scale were used. In the analysis of the collected data, frequencies, percentages, independent-samples t-test and one-way variance analysis (ANOVA), PostHoc Tests (Tukey and Dunnett's C) and correlation analysis were used. The findings of the present study have revealed that the middle school students' self-regulation skills and vocabulary learning strategies in foreign language are over the medium value. The middle school students' self-regulation skills and vocabulary learning strategies in foreign language were found to vary significantly depending on gender, grade level, father-mother attitude and level of interest in English course. A medium, positive and significant correlation was found between the middle school students' total scores of self-regulation strategies and vocabulary learning strategies in foreign language.