E-learning is considered as an important component of enhancing teaching and learning processes by Higher Learning Institutions in Tanzania. In the context of teaching and learning, e-learning encompasses the use of information, computers and technology to enhance communication in distance learning. This paper discusses the applicability of e-learning in Higher Learning Institutions (HLIs) in Tanzania using three selected universities in the Morogoro Region. Data were collected using questionnaires and interviews among a sample 90 respondents, who were selected using simple random and purposive sampling techniques. Data were analysed through descriptive statistics and results presented using frequency and mean statistics. The results revealed that there is limited applicability of e-learning in the three HLIs studied. The inadequate applicability of e learning is attributed to poor attitude, lack of skills among the users and insufficient ICT infrastructure. The study therefore recommends that the government allocate funds to ensure that universities are well equipped with ICT facilities and also ensure an ICT curriculum is taught from primary school to higher education levels so as to enhance students' attitude towards e-learning.