Texts and pictures are often combined in order to improve learning. Many students, however, have difficulty to appropriately process text-picture combinations. We have thus conceptualized a learning strategy which supports learning from illustrated texts. By inducing the processes of information selection, organization, integration, and transformation, the learning strategy should lead to a more elaborated learning. After conducting a pilot study, a main study with 133 sixth-grade students from two different middle schools was carried out in order to analyse the learning effectiveness of the strategy. One group of students learned without the strategy whereas the second group learned with the strategy. All students had to complete a pre-test as well as a post-test which followed the learning period. The learning outcomes of the two groups were then compared: both studies demonstrated that the students who employed the strategy attained significantly better learning results. The effect sizes are medium to large.