In response to the calls to improve and deepen scientific understanding and literacy, considerable effort has been invested in developing sustainable technology-enhanced learning environments to improve science inquiry. Research has provided important guidance for scaffolding learning in mathematics and science. However, these reports have provided relatively little insight into how the different types of scaffolds can (or should) be implemented in dynamic, everyday classroom settings. In this qualitative case study, we examined how students solve scientific problems in technology-enhanced classrooms and how peer-, teacher-, and technology-enhanced scaffolds influenced student inquiry. The results indicated that students manifested distinct inquiry patterns when solving scientific problems and integrated different types of scaffolds to facilitate inquiry activities. These findings suggest that to support scientific inquiry in problem-solving contexts, technology-enhanced scaffolds are effective when supported by clear project goals, relevant evidence, peer- and teacher-assessments, and exemplars of knowledge articulation.