In the Bible, the Four Horsemen of the Apocalypse are said to usher in the end of the world. That is why, in 1964, Judge Ben Cameron gave four of his fellow judges on the United States Court of Appeals for the Fifth Circuit the derisive nickname "the Fifth Circuit Four"--because they were ending the segregationist world of the Deep South. The conventional view of the civil rights struggle is that the Southern white power structure consistently opposed integration. While largely true, one of the most powerful institutions in the South, the Fifth Circuit, helped to break civil rights barriers by enforcing the Supreme Court's decision in "Brown v. Board of Education," something that other Southern courts were reluctant to do. Despite personal and professional backlash, Judges John Minor Wisdom, Elbert Tuttle, Richard Rives, and John Brown played a significant but often overlooked role in integrating the South. This article discusses the background of the Fifth Circuit, the Fifth Circuit's role in enforcing "Brown v. Board of Education" in the deep south, and backlash against the Fifth Circuit Four.