About three in ten Americans with hypertension do not take medication to control their blood pressure. The risk and protective factors of non-adherence to prescribed anti-hypertensive medication have not been well investigated. Participants who were aware of their hypertension, advised by healthcare professional to take anti-hypertensive medication but were not adhering to treatment recommendations (n=8,416) were retrieved from 2017 Behavioral Risk Factor Surveillance System (BRFSS) survey. A series of 30 related variables were selected and analyzed using bivariate logistic and stepwise multiple logistic regression analysis. The results showed that participants who had a primary health care provider (OR=6.79), had a routine checkup (OR=5.48), had a flu shot or spray (OR=2.85), were unemployed (OR=2.35), not binge drinking (OR=2.09), annual household income $10,000 or higher (OR=1.77), female (OR=1.69), without depression (OR=1.41), and did not do exercise in past 30 days (OR=1.40) significantly predicted adherence to anti-hypertensive medication. The younger a participant was, the lower the likelihood of adherence. Patient education and healthcare services that aims to educate/serve younger males who do not have a primary healthcare provider, a routine checkup, and a flu shot/spray are suggested. Future studies should focus on prevention and management of high-risk populations.