Each year since 1997, the Federal Interagency Forum on Child and Family Statistics has published a report on the well-being of children and families. The Forum's signature report, "America's Children: Key National Indicators of Well-Being," provides annual updates on the well-being of children and families in the United States across seven domains: family and social environment, economic circumstances, health care, physical environment and safety, behavior, education, and health. This year's report reveals that health insurance coverage rates for children increased, the percentage of preterm births declined for the second straight year, average 8th-grade mathematics scores reached an all-time high, teen smoking was at its lowest since data collection began, and the adolescent birth rate declined after a 2-year increase. However, the percentage of children whose parents had secure employment was the lowest since 1996, and the percentage living in poverty was the highest since 1998. The percentage of children in food-insecure households was the highest since monitoring began. The Brief concludes with a summary table displaying recent changes in all 40 indicators. (Contains 15 figures and 40 footnotes.)