Neurodivergent youth (i.e., autistic, attention-deficit hyperactivity disorder) are at increased risk for school refusal and subsequent disengagement. Factors associated with school refusal in this population remain unclear. Latent profile analysis was conducted to identify profiles of school and demographic variables associated with parent-reported school refusal for 508 neurodivergent and community youth (ages 6-17 years). Five profiles were identified, including three groups characterized by frequent school refusal, high levels of neurodivergent traits, and frequent peer victimization. Differentiation was noted via educational placement, support needs, mental health, and bullying. Implications concern identification and intervention for subgroups of neurodivergent youth.