The goal of this study is to investigate the efficacy of psychoeducational interventions geared to reducing psychological distress for caregivers in a sample of 90 family caregivers of elderly dependent (78 women and 12 men). We conducted an analysis of the statistical and clinical significance of the changes observed in psychological health before and after a psychoeducational intervention in two therapeutic modalities: one in a face-to-face group format (n?=?69), and another in a distance format (n?=?21). Bivariate correlations and regression analysis were performed to analyze the relationship between the predictive variables and the score on mental health changes. The results obtained suggest that the benefits of psychoeducational interventions on caregivers' distress, regardless of the therapeutic modality, is of clinical importance. Caregiver burden was the best predictor of improvement after psychoeducational interventions, with lower work satisfaction being particularly noticeable.