The current study assessed 495 middle school students in China using self-report questionnaires, to examine the multiple mediating effects of intrinsic motivation and learning engagement (vitality, dedication and absorption) in the relations between technology acceptance and students' self-regulated learning. The results indicated that technology acceptance had a significant impact on self-regulated learning, intrinsic motivation mediated the relations between technology acceptance and self-regulated learning, and learning engagement (vigor, dedication, and absorption) mediated the relations between technology acceptance and self-regulated learning. The findings suggested that students' perceived acceptance of technology can help them improve their ability to engage in self-regulated learning by enhancing intrinsic motivation and increasing learning engagement. The results expand our understanding of self-regulated learning for Chinese middle school students in the context of information technology, and have substantial theoretical and practical implications for educator and relevant researchers.