Drawing partly on publicly accessible commentary on 2015 Programme for International Students Assessment (PISA) scores (Organisation for Economic Cooperation Development, [OECD], 2016), this article reminds educators of the need to reflect on past, present, and possible future interventions and strategies to help "all" students be academically successful. Discussion includes how a STEM/STEAM-based 21st century skills framework can have a positive impact on student achievement by creating an engaging, challenging, rigorous, student-centered teaching and learning environment. The article stresses the importance of taking a unified ecological approach involving home, school, and community settings when attempting to understand how and why students have been academically successful, and conversely unsuccessful. Reminding educators of the importance of reform across the entire PK-21 setting, this article provides a timely (re)discussion of a perennial yet crucial educational topic on how to meet the needs of current and future students in a rapidly changing world.