This article explores ACT UP (AIDS Coalition to Unleash Power) through a Freirean lens of critical consciousness, dialogue, and transformation. The purpose is to draw from where there have been processes of engagement of sociopolitical action in science and how these spaces can become meaningful entry points to take toward making a "sociopolitical turn" in science education, as well as in science more broadly. Current practices in science education do not adequately prepare educators and students to challenge and interrupt injustices that we are emersed in. ACT UP is a well-studied example of when non-specialists engaged with science and scientific knowledge making to shift power and policy. Paulo Freire's pedagogy was developed alongside social movements. By examining ACT UP through a Freirean lens, I explore themes of relationality, social epistemology, consensus, and dissensus that emerged when a social movement engaged with science to achieve its goal. My intent is to add to the ongoing dialogues of approaching science education as a practice of critical consciousness and liberatory world making.