Objective: The aim of this study is to investigate whether smoking affects the quality of life of the students at Medical Documentation and Secreteriat Program (MDS) of Health Services Vocational Colleges. Methods: In this cross-sectional study, the questionnaire has been applied to 147 (73,5 %) students out of 200 MDS students. As data collecting tool, a questionnaire developed by the researcher and Short Form 36 (SF-36) were used. The chi-square test, pearson correlation and logistical regression analysis were used in the statistical analysis. Results: In all the domains of quality of life, the scores of non-smoker students were found to be higher than the smokers. This height was significant for the domains of pain (BP) and physical health mean scores. In all the domains of quality of life except for BP and general health perception (GH), heavy smokers ([greater than or equal to]20 cigarettes per day) had lower scores of life quality than light and moderate smokers. This lowness was significant for the domain of physical role limitations (RP). The quality of life scores of the students having smoking-related health problems were lower than the scores of those who did not have health problems. This lowness was significant for the domains of BP and GH. The quality of life scores of the students with smoking family members were lower than the non-smokers. The life quality scores of the students who desired professional help to stop smoking were lower than those who do not. This lowness was significant for the GH, RE and mental health summary (MCS) domains. A negatively significant correlation between the number of the cigarette pieces a day and RP, RE and mental health scores of quality of life was identified. A negatively significant correlation between the expenses for smoking and RP, RE, MCS was also identified. Conclusion: The life quality scores of the smoking students are lower. (Contains 5 tables.)