Main clause phenomena (MCPs) are syntactic constructions that occur predominantly or exclusively in main clauses. I propose a processing explanation for MCPs. Sentence processing is easiest at the beginning of the sentence (requiring less search); this follows naturally from widely held assumptions about sentence processing. Because of this, a wider variety of constructions can be allowed at the beginning of the sentence without overwhelming the sentence-processing mechanism. Unlike pragmatic and grammatical accounts of MCPs, the processing account predicts avoidance of MCPs in non-initial main clauses (non-initial coordinate clauses and premodified clauses). A corpus study supports these predictions, but it is somewhat inconclusive. A further corpus study examines another type of syntactic construction, premodifying adjunct phrases ("openers"); the prediction here is that less common types of opener will be especially avoided in non-initial contexts. The prediction is confirmed, supporting the processing view of rare constructions.