Significant investments have been made in the last five years to further strengthen the relationship between the United Kingdom (UK) and African continent for science and innovation partnerships. This has enabled the enhancement of longstanding relationships for joint research and development activities as well as the establishment of new, innovative partnerships between key actors driving change in the Africa-UK research and innovation landscape. A high-level meeting of research sector leaders from across Africa and the UK in March 2021. The aim was to reflect on the challenges and successes of past activities and to set out a vision for future success that will see continued and improved impact of Africa-UK research and innovation partnerships, across three priority areas: (1) Enhancing research partnerships to tackle global inequalities; (2) Embedding international collaboration in the next generation of researchers; and (3) Strengthening research systems for more and better research. The following recommendations have been set out for higher education institutions, funders and policymakers with the aim of enabling sustained, equitable and reciprocal research and innovation partnerships between Africa and the UK. [The document was prepared with the African Research Universities Alliance (ARUA) and the UK Research and Innovation (UKRI).]